During normal production of coal mines, when there are no obvious signs of spontaneous combustion on the working face, there is often a high concentration of CO accumulation in the upper corner, which leads to exceeding the limit of CO concentration, severely restricting the mining progress, interfering with coal spontaneous combustion monitoring and warning, and even posing a threat to the health and life of miners. In this paper, a copper-loaded adsorbent was prepared, and experiments were conducted on the specific surface area, pore structure, and X-ray diffraction of the adsorbent, as well as the elimination amount and elimination rate of the adsorbent were determined. The experimental results showed that the molecular sieve adsorbent loaded with cuprous chloride had a decreased specific surface area and pore volume, and an increased average pore diameter. The XRD test results showed that cuprous chloride was dispersed in a single layer on the carrier, and the molecular sieve loaded with cuprous chloride had the best effect. The results of the static elimination experiment in a closed space showed that after the adsorbent was added for the first time, the CO concentration dropped sharply, and after 10 minutes, the decrease became gradual and reached a plateau at 15 minutes. After adding the adsorbent again, the trend of CO concentration change was the same as the first time, but the rate of decrease was slower than the first time. In addition, the molecular sieve adsorbent loaded with cuprous chloride had the best elimination effect, with a maximum elimination amount of 230 ppm and an elimination rate of 61.17%. The results of the dynamic elimination performance test showed that using the molecular sieve adsorbent loaded with cuprous chloride, the best elimination performance was obtained when the wind speed was 1.0 m/s, the adsorbent mass was 600 g, and it was placed in the middle of the pipeline, with a maximum instantaneous elimination amount of 82 ppm. The importance of the factors affecting the adsorbent elimination performance was determined by orthogonal experimental design as follows: adsorbent mass > adsorbent position > wind speed. The research results provide theoretical guidance for the CO elimination process on the upper corner of the coal mining face.