Resilience is a hot topic in global change and environmental development research, providing a new research framework and practical analytical tools for regional sustainable development studies. This study combines the human-sea regional system with resilience to construct a theoretical logical framework for the resilience of the human-sea regional system. It integrates internal factors and external disturbances, obtains multi-source data, combines hierarchical analysis, kernel density analysis, and GIS spatial analysis methods to construct an indicator system, and uses exploratory data analysis (ESDA) methods to analyze the evolution of spatial resilience and the characteristics of land-sea gradient characteristics. The main results are as follows. (1) The spatial resilience of the human-sea regional system in Dalian city presents a distribution characteristic of "low in the middle, high in the south and north, low along the coast, high inland," and it is increasing year by year. The coastal and inland regions exhibit distinct regional differences. (2) It has a spreading effect, with new hot and cold spots sporadically increasing around the continuous hot and cold spots. (3) The resilience of the geographical system of human-sea relations in Dalian city has obvious land-sea gradient characteristics. The resilience of each criterion layer is, in descending order, the resilience of the ecological environment, the resilience of climate change, the resilience of the resource level as well as the resilience of human activities; the overall resilience presents the gradient characteristics of the resilience level that is higher the further away from the sea it is. Therefore, the resilience regulation of coastal cities can be combined with the characteristics of the land and sea gradient to carry out sub-district and sub-featured governance on a micro level, and improve the level of development of the marine economy on a macro level based on guaranteeing a low-carbon economy, and formulate a blueprint for the development of a blue-carbon economy.