The  current  age  of  information  technology  has  seen  the  rise  of  increasingly  autonomous  systems  where  human  intelligence  is  augmented  with  machine  intelligence, and the roadmap for adopting autonomous technologies in aviation  is  ramping  up.  As  we  move  to  accept  increased  autonomy  in  flight  systems, in drones, UAS platforms, larger air transport, and in their interactions with  ground  and  space-based  systems,  the  need  to  assure  the  safety  and  verification of these technologies is paramount, particularly for those technologies that incorporate learning enabled functionality. Integrating these  technologies  within  the  air  transport  system  while  maintaining  safety  and  security  requirements  will  effectively  reveal  assurance  challenges  which  will,  over  time,  produce  certification  requirements  beneficial  to  both  design  and  operations  at  the  appropriate  level  of  risk.  Beyond  certification,  there  are  ethical  and  environmental  considerations  along  with  liability  concerns surrounding autonomous machine decisions, especially while managing emergency operations. The 41st DASC will explore the technology roadmap that will  enable  increasingly  autonomous  systems  that  incorporate  humans  and  machines along with formulations that can aid the future certification of these systems for air transportation.  Conference participants are invited to submit cutting edge research papers and exchange diverse perspectives on how the industry currently is or how it should be realizing the vision for autonomy in the future.  Original  research  on  technical  challenges,  gaps,  and  approaches  to  enhance  traditional  ATM,  UAS,  CNS,  IMA,  security,  space  systems,  and  human  factors are encouraged.