The emerging modern mobile robotic systems and intelligent information systems are becoming increasingly ubiquitous and distributed, where they are intended to operate in highly dynamic and continuously fluctuating societal and economic environments. Moreover, the introduction of autonomous systems has revolutionized a wide range of applications like agriculture, healthcare, education, military, industries, and so on. The 2nd International Conference on Machine Learning and Autonomous Systems [ICMLAS 2025] on 10-12 March, 2025 will be an interdisciplinary platform for the researchers to contribute their research works that address the state-of-the-art technologies, development, and methodologies for the futuristic intelligent autonomous system developments and applications.