Regulatory mechanisms that maintain energy homeostasis are vital to metabolic health. While short-term adaptation to energy balance challenges relies heavily on post-translational modifications, long-term adaptive responses require transcriptional networks that sense energy-state and metabolic stressors and execute gene expression programs in a signal- and context-dependent manner. Such transcriptional networks can determine pathways controlling energy balance, physiological responses to changes in energy state, and the development of pathophysiological states that manifest as metabolic disease. Elucidation of the transcriptional networks and the underlying regulatory mechanisms can facilitate therapeutic approaches aiming at altering energy balance, e.g. by increasing energy expenditure, or ameliorating the complications arising from states of excess positive energy balance, e.g. hepatic steatosis, T2 diabetes, and cardiovascular disease. Nuclear receptors (NRs), a family of ligand-dependent transcription factors that sense hormones, dietary lipids, and vitamins, co-operate with NR cofactors to regulate diverse aspects of metabolism. The meeting will weave the roles of NRs and NR cofactors with the roles of other types of transcription factors that carry important functions in integrating signal- and context-dependent information and enabling appropriate adaptive metabolic responses. Our goal is to bring together junior and senior investigators that study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease.