Proteases co-evolved with their substrates as integral components of specific networks or pathways in development and homeostasis. Elucidating their role in disease, resulting either from loss of function or over-expression, requires a sophisticated understanding within the context of biological networks. Furthermore, successful development of novel therapies relies on an integrated, multidisciplinary approach to investigating such networks and pathways. The 2013 GRC on Matrix Metalloproteinases will develop these themes in the context of major functional networks, and will be inclusive of multiple organ/biological systems and a variety of disease pathways. The conference will feature fundamental and applied research on all aspects of MMPs, ADAM, ADAMTS, and astacin metalloproteinases, as well as their natural and synthetic inhibitors to highlight general principles as well as specific properties. The role of these metalloproteinases in molecular maturation and turnover in diverse biological systems and models is a major focus. In addition, disease-causing protease mutations, proteolytic mechanisms in acquired diseases, protease regulatory mechanisms at all levels, structural biology, developmental biology, genetics, and therapeutics will constitute the broad scope of the meeting. Speakers will summarize the most exciting recent developments in their fields, identify the major unanswered questions, and share novel, unpublished data from their laboratories. The GRC on Matrix Metalloproteinases is an international forum that welcomes junior and established scientists from all disciplines to participate, and features scientists from both academia and industry. All applicants are encouraged to submit abstracts and a significant proportion of the oral program will be selected from submitted abstracts. Poster sessions as well as abundant time for social activities provide excellent opportunities for interactions. The informal nature of the conference promotes interdisciplinary interactions and stimulating discussions in a spirit of collegiality and collaboration. The 2013 GRC on Matrix Metalloproteinases will again offer a Gordon Research Seminar (GRS) organized along the theme of the GRC, which will be held immediately preceding the GRC on Matrix Metalloproteinases. The GRS is a two-day program designed specifically for junior investigators, such as students, postdocs, and clinical trainees. The 2011 GRS was very successful and the attendees had expressed strong enthusiasm for this activity to continue. The Chair and Vice-chair of the 2013 GRS are Sean Gill (Univ of Washington) and Alisha Mendonsa (Vanderbilt University). The GRS offers unparalleled opportunities for peer-peer interaction, oral and poster presentations, and other activities focused on the needs of junior investigators. It is hoped that all GRS attendees will also participate in the GRC.