In the 50 years since RNA was identified as a central component in the flow of genetic information, it has become increasingly clear that RNA is more than a mere messenger and performs many diverse and interesting functions. RNAs are known to play central roles across numerous biological processes required for cell viability and function. Moreover, prokaryotic and eukaryotic genomes are pervasively transcribed to generated many additional RNAs with unknown functions, raising the question: What else does RNA do?