We are very honored to invite you to participate in the IEEE International Conference on e-Health and Bioengineering, EHB 2013, which will take place in ROMANIA, in the city of Iaşi. This year the conference motto is "Improving Quality of Life through Research and Innovation," and we need to stress that the goal mentioned in the motto cannot be achieved without an efficient use of information and management systems and biomedical technology. The 4-th edition of this biannual conference is organized by Grigore T. Popa University of Medicine and Pharmacy of Iaşi and Romanian Society of Medical Bioengineering, under the aegis and technical sponsorship of the IEEE (Please visit www.embs.org to participate in other conference opportunities), IEEE Romania Section and IEEE-EMB Romania Chapter, and co-organized by the Institute of Computer Science of Romanian Academy Iasi Branch. The conference is mainly dedicated to the e-health systems, medical bioengineering and biomedical engineering. Its specific goals are to promote concepts and advanced hardware and software technologies in the emerging domains of e-health, medical devices and instrumentation, biosignal and image processing, medical informatics, biomechanics, biomaterials, biotechnologies, medical physics, healthcare management, teaching and (e)learning, rehabilitative and assistive technologies, as well as in some younger disciplines such as bioinformatics, systems biology and the virtual physiological human. The major purpose of our initiative is to contribute to the reinforcement of the four pillars of a modern health care which include: · Improved Quality · Improved Safety · Increased Cost-Effectiveness · Increased Access to Care. Another permanent objective of our conference is to strengthen the interdisciplinary synergy between medical and technical researchers and practitioners, within the generous framework of medical bioengineering. Moreover, a special attention has to be granted in the future to targeting research to the real needs of the patients of the 3-rd millennium, through different national and international projects, partnerships and collaborations. As it is well known, today medicine cannot be thought and practiced without the help of Information Technology and Telecommunications (IT&C) and computers are used more and more together with medical equipment and physicians' working set. In fact, all the domains of clinical and experimental medicine have been developed with the direct help of IT&C. Thus, a future big challenge for the health care domain will be the creation of an effective National Health Information Network, which will link all practitioners in the country and will be connected to similar European infrastructures. As the European Commission recommends, this issue must be a permanent concern at the highest level of European governmental institutions.