We are pleased to announce the second Cold Spring Harbor meeting on Wiring the Brain, which will begin at 7:30 pm on Tuesday March 24 and run through lunchtime on Saturday March 28, 2015. Previous meetings in this series took place in Ireland in 2009 and 2011 and at CSHL in 2013. The main goal of this meeting is to bring together researchers from diverse fields to explore how brain connectivity is established, how genetic variation can affect these processes, how circuit and network function are affected by defects in neural development and how this can lead to psychiatric and neurological disease.