The IEEE International Conference on Biomedical and Health Informatics (BHI) is a special topic conference of IEEE Engineering in Medicine and Biology Society (IEEE-EMBS). BHI2016 is co-located with the Annual HIMSS Conference & Exhibition in Las Vegas, NV, USA. The main theme of the BHI2016 is the “Integrative informatics for precision and preventive medicine.” Advancing health informatics has been identified as a grand challenge for engineering in the 21st century by the National Academy of Engineering. Maintaining and improving human health will require integrative and novel informatics solutions to better translate discovery into clinics, re-engineer care practices, and integrate big data of various health networks. The BHI2016 will provide a unique forum to showcase enabling technologies of computing, devices, imaging, sensors, and systems that optimize the acquisition, transmission, processing, storage, retrieval, visualization, analysis.